William R Jacobs Selected Research

Mycolic Acids (Mycolic Acid)

8/2013	Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis.
12/2010	Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis.
7/2008	Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
6/2008	Mycolic acid modification by the mmaA4 gene of M. tuberculosis modulates IL-12 production.
6/2007	Isolation and analysis of Mycobacterium tuberculosis mycolic acids.
3/2007	Deletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice.
6/2006	Trans-cyclopropanation of mycolic acids on trehalose dimycolate suppresses Mycobacterium tuberculosis -induced inflammation and virulence.

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William R Jacobs Research Topics

Disease

123	Tuberculosis (Tuberculoses) 02/2021 - 02/2002
42	Infections 01/2021 - 01/2004
5	Malaria 02/2013 - 04/2002
4	Starvation 01/2021 - 08/2003
4	Persistent Infection 01/2019 - 05/2006
4	Necrosis 01/2016 - 10/2006
3	Extensively Drug-Resistant Tuberculosis 10/2020 - 01/2009
3	Hypersensitivity (Allergy) 01/2016 - 06/2006
3	Hypoxia (Hypoxemia) 08/2014 - 09/2003
3	Inflammation (Inflammations) 07/2010 - 06/2006
2	Human Influenza (Influenza) 01/2021 - 08/2004
2	Neoplasms (Cancer) 01/2020 - 05/2013
2	Communicable Diseases (Infectious Diseases) 01/2019 - 01/2017
2	Bovine Tuberculosis 01/2016 - 01/2016
2	Granuloma 01/2016 - 01/2008
2	Latent Infection 05/2014 - 03/2007
2	HIV Infections (HIV Infection) 01/2014 - 01/2014
2	Pulmonary Tuberculosis 01/2011 - 07/2009
2	Poisoning 12/2010 - 05/2010
2	Cardiomyopathies (Cardiomyopathy) 02/2004 - 05/2003
1	Blindness (Hysterical Blindness) 01/2020
1	Vaginal Diseases 01/2020
1	Lymphoma (Lymphomas) 01/2020
1	Virus Diseases (Viral Diseases) 01/2020
1	Vesicular Stomatitis 01/2020
1	Herpetic Keratitis 01/2020
1	Disease Progression 01/2019
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2018

Drug/Important Bio-Agent (IBA)

37	VaccinesIBA 01/2021 - 10/2002
26	Pharmaceutical PreparationsIBA 10/2020 - 10/2002
13	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 03/2005
10	Proteins (Proteins, Gene)FDA Link 01/2018 - 10/2002
9	AerosolsIBA 12/2016 - 10/2003
8	Isoniazid (Ftivazide)FDA LinkGeneric 01/2018 - 06/2003
8	CytokinesIBA 01/2017 - 09/2004
8	AntigensIBA 12/2016 - 01/2008
7	Mycolic Acids (Mycolic Acid)IBA 08/2013 - 06/2006
6	Rifampin (Rifampicin)FDA LinkGeneric 01/2018 - 10/2012
6	BCG Vaccine FDA Link 01/2017 - 01/2003
5	EnzymesIBA 01/2019 - 09/2007
4	AntibodiesIBA 01/2021 - 06/2006
4	Glycoproteins (Glycoprotein)IBA 01/2021 - 03/2015
4	Immunoglobulin G (IgG)IBA 01/2020 - 06/2006
4	Interleukin-17 (Interleukin 17)IBA 01/2016 - 07/2010
4	LipidsIBA 09/2014 - 06/2006
4	Lysine (L-Lysine)FDA Link 01/2011 - 05/2003
4	Oxidoreductases (Dehydrogenase)IBA 11/2009 - 06/2003
3	Leucine (L-Leucine)FDA Link 01/2021 - 01/2008
3	Arginine (L-Arginine)FDA Link 01/2021 - 01/2018
3	Tuberculosis VaccinesIBA 01/2021 - 04/2009
3	Ascorbic Acid (Vitamin C)FDA LinkGeneric 01/2020 - 01/2013
3	Antitubercular AgentsIBA 01/2019 - 02/2009
3	TrehaloseIBA 12/2016 - 06/2006
3	Interferon-gamma (Interferon, gamma)IBA 01/2016 - 09/2004
3	GlucansIBA 01/2016 - 05/2010
3	AcidsIBA 05/2014 - 03/2007
3	Interleukin-2 (IL2)IBA 08/2013 - 01/2011
2	Methionine (L-Methionine)FDA Link 01/2021 - 01/2018
2	Hemagglutinins (Hemagglutinin)IBA 01/2021 - 08/2004
2	EpitopesIBA 01/2020 - 07/2004
2	Streptomycin (Streptomycin Sulfate)FDA Link 01/2017 - 01/2016
2	SAIDS VaccinesIBA 01/2017 - 11/2013
2	IronIBA 10/2016 - 03/2014
2	Immunoglobulin A (IgA)IBA 08/2016 - 11/2013
2	Green Fluorescent ProteinsIBA 01/2016 - 10/2007
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 11/2014 - 08/2014
2	Lipoproteins (Lipoprotein)IBA 09/2014 - 03/2006
2	NAD (NADH)IBA 08/2014 - 04/2010
2	Fatty Acid Synthases (Fatty Acid Synthase)IBA 11/2012 - 08/2011
2	Peptidoglycan (Murein)IBA 02/2012 - 03/2006
2	Interleukin-12 (IL 12)IBA 01/2012 - 06/2008
2	Pyrazinamide FDA LinkGeneric 08/2011 - 07/2004
2	maltose 1-phosphateIBA 12/2010 - 05/2010
2	AgarIBA 09/2009 - 10/2003
2	signal peptidase II (premurein-leader peptidase)IBA 09/2009 - 03/2006
2	A-Form DNA (A-DNA)IBA 07/2009 - 08/2004
2	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 06/2009 - 09/2004
2	Fatty Acids (Saturated Fatty Acids)IBA 12/2008 - 04/2002
2	LuciferasesIBA 11/2008 - 01/2003
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2008 - 05/2006
1	Acetylcysteine (Siran)FDA LinkGeneric 02/2021
1	InterferonsIBA 01/2021
1	Influenza Vaccines (Influenza Vaccine)FDA Link 01/2021
1	Linezolid (Zyvox)FDA Link 10/2020
1	telacebecIBA 10/2020
1	bedaquiline (R207910)IBA 10/2020
1	pretomanidIBA 10/2020
1	5-hydroxymethylcytosineIBA 01/2020
1	Viral VaccinesIBA 01/2020
1	Protein Subunits (Protein Subunit)IBA 01/2020
1	Neutralizing AntibodiesIBA 01/2020
1	Type VII Secretion SystemsIBA 01/2019
1	Aspartic Acid (Aspartate)FDA Link 01/2019
1	4-hydroxy-3-methyl-2-butenyl diphosphateIBA 01/2019
1	Amino Acids FDA Link 01/2018
1	Ribosomal Proteins (Ribosomal Protein)IBA 01/2018
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	Peptide LibraryIBA 01/2018

Therapy/Procedure

8	Drug Therapy (Chemotherapy) 01/2019 - 10/2003
6	Therapeutics 01/2020 - 07/2008